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Related categories: APIs; biochemical reagents; microbial metabolites; pharmaceutical intermediates; antibiotics; fermentation; raw materials; small molecule inhibitors, natural products;
Nature
Melting point95-97°C
Specific rotationD21 -35° (c = 0.7 in methanol)
Density1.136
Storage conditionsStore at -20°C
colourcolorless
InChIKeyQXRSDHAAWVKZLJ-PVYNADRNSA-N
CAS database152044-54-7
Use
(-)-Epothilone B is a stable drug of microtubule (MT) derived from the natural mucobacteria Sorangium cellulosum, which is a macrolide antitumor factor. EpoB is similar to EpoA in its biological properties. However, in potent anti-P-glycoprotein expression multidrug resistance (MDR) cells (IC50 = 2 nM for MDR CCRF-CEM/VBL100 cells), EpoB was 10 times more potent than EpoA. (-)-Epothilone B is similar to paclitaxel and is an alternative to paclitaxel in cell growth. EpoB causes cell cycle arrest (IC50 = 3.5 nM).buy Chemical intermediate
website:http://www.dlskychem.com/pharmaceutical-intermediates/
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